The Influence Of Ozonized olive oil gel on the dorsal surface of the tongue ofstreptozotocin induced diabetic albino rats

Background: It has been a growing interest recently in use of non-medication methods in management of medical diseases as diabetes. Nevertheless, most studies have focused only on their ability to maintain blood glucose levels, and have not been investigated for their beneficial effects on secondary complications of diabetes such as oral lesions. Therefore, the current study aimed. The aim of the current study is to evaluate the possible effect of ozone in ameliorating the histological changes in the lingual papillae of diabetic rats experimentally induced by streptozotocin. Methods: Thirty adult male albino rats were divided into 3 equal groups: group I; (control group), group II; (diabetic group):diabetes was induced by a single intraperitoneal injection of streptozotocin in a dose of 65 mg/kg and group III;(Ozone group) rats were treated as in diabetic group for 4 weeks then ozone gel was applied on the tongue mucosa daily for 2 weeks. By the end of the experimental periods all animals were sacrificed and the tongue of all rats were dissected and processed for light and scanning electron microscopic examinations. Results: Examination of dorsal surface of diabetic rats' tongues revealed numerous filiform papillae with evidently disturbed orientation and inclination. Some of them depicted notched or bifurcated ends; others were severely destructed with desquamation of its epithelial covering. There were hyperkeratosis and markedly reduced CT papillae. Disfigured fungi form papillae with vacuolated taste buds depicting peripheral arrangement of the cells and empty center were also seen. Dorsal surface of rats' tongues of the ozone group revealed almost normal direction, distribution and structure of the papillae and taste buds. Conclusion: From the present study we concluded that diabetes has a deleterious effect on tongue papillae and taste buds. Fortunately ozone gel provided considerable treatment of these effects. [Heba Mohamed Eltokhey. The Influence of Ozonized olive oil gel on the dorsal surface of the tongue ofstreptozoptocininduced diabetic albino rats. J Am Sci 2013;9(10):193-201]. (ISSN: 1545-1003). http://www.jofamericanscience.org. 25